{"id":13955,"date":"2022-08-16T09:48:18","date_gmt":"2022-08-16T08:48:18","guid":{"rendered":"https:\/\/www.lactalisingredients.com\/?post_type=blog-post&p=13955"},"modified":"2026-02-26T16:30:28","modified_gmt":"2026-02-26T15:30:28","slug":"effet-satietogene-des-proteines-laitieres","status":"publish","type":"blog-post","link":"https:\/\/www.lactalisingredients.com\/fr\/news\/blog\/effet-satietogene-des-proteines-laitieres\/","title":{"rendered":"Effet sati\u00e9tog\u00e8ne des prot\u00e9ines laiti\u00e8res"},"content":{"rendered":"

Parmi tous les nutriments pr\u00e9sents dans les aliments, les prot\u00e9ines sont r\u00e9put\u00e9es pour avoir un effet sur la sati\u00e9t\u00e9. De nombreux travaux (in vitro, in vivo et cliniques) ont en effet montr\u00e9 que les prot\u00e9ines avaient la capacit\u00e9 \u00e0 moduler les signaux de la sati\u00e9t\u00e9, et donc l\u2019\u00e9tat de faim.<\/em><\/p>\n

Les prot\u00e9ines laiti\u00e8res n\u2019\u00e9chappent pas \u00e0 cette r\u00e9putation favorable sur la sati\u00e9t\u00e9, et font m\u00eame partie des prot\u00e9ines les plus explor\u00e9es par la science. D\u2019ailleurs, les \u00e9pid\u00e9miologistes mettent souvent en avant l\u2019effet sati\u00e9tog\u00e8ne des prot\u00e9ines laiti\u00e8res, pour expliquer la corr\u00e9lation entre forte consommation de produits laitiers et moindres risques de diab\u00e8te de type 2\/syndrome m\u00e9tabolique.<\/em><\/p>\n

Prot\u00e9ines laiti\u00e8res et sati\u00e9t\u00e9 : m\u00e9canismes d\u2019action<\/strong><\/span><\/h2>\n

Induction de sati\u00e9t\u00e9 par les acides amin\u00e9s<\/strong><\/p>\n

Plusieurs m\u00e9canismes sont sugg\u00e9r\u00e9s par les \u00e9tudes scientifiques pour expliquer l\u2019effet sati\u00e9tog\u00e8ne des prot\u00e9ines laiti\u00e8res. Le premier m\u00e9canisme provient des acides amin\u00e9s eux-m\u00eames, et explique de mani\u00e8re g\u00e9n\u00e9rale pourquoi les prot\u00e9ines ont un effet sati\u00e9tog\u00e8ne. D\u2019abord, le cerveau est capable de d\u00e9tecter le niveau d\u2019acides amin\u00e9s circulant, et de g\u00e9n\u00e9rer selon ces niveaux des signaux de sati\u00e9t\u00e9 3<\/a><\/sup>. Dans la mesure o\u00f9 les acides amin\u00e9s \u00e0 cha\u00eene branch\u00e9e (BCAA) peuvent \u00eatre utilis\u00e9s comme carburant par le cerveau, ces acides amin\u00e9s \u2013 tr\u00e8s pr\u00e9sents dans les prot\u00e9ines de lactos\u00e9rum \u2013 induisent donc un signal de sati\u00e9t\u00e9. Ensuite, le tryptophane et la tyrosine servent \u00e0 la production de plusieurs neurotransmetteurs (notamment la s\u00e9rotonine et les cat\u00e9cholamines), impliqu\u00e9s dans le contr\u00f4le de la prise alimentaire 4<\/a><\/sup>.<\/p>\n

Production de peptides bioactifs \u00e0 partir des prot\u00e9ines de lait<\/strong><\/p>\n

Le second m\u00e9canisme, sp\u00e9cifique aux prot\u00e9ines laiti\u00e8res, vient de leur capacit\u00e9 \u00e0 g\u00e9n\u00e9rer des peptides bioactifs \u00e0 l\u2019issue de leur digestion. C\u2019est l\u2019action combin\u00e9e des enzymes digestives, mais aussi probablement du microbiote intestinal, qui est \u00e0 l\u2019origine de ces peptides. Au moins 26 peptides ont \u00e9t\u00e9 identifi\u00e9s au sein des prot\u00e9ines laiti\u00e8res 4<\/a><\/sup>. Les \u03b2-casomorphines, d\u00e9riv\u00e9es des cas\u00e9ines, influencent ainsi directement la motilit\u00e9 gastro-intestinale (la capacit\u00e9 de l\u2019organisme \u00e0 faire avancer les aliments le long de l\u2019intestin), la s\u00e9cr\u00e9tion d\u2019insuline et la prise alimentaire 9<\/a><\/sup>. L\u2019\u03b1-lactorphine, d\u00e9riv\u00e9e quant \u00e0 elle des prot\u00e9ines de lactos\u00e9rum, poss\u00e8de des effets similaires 8<\/a><\/sup>.<\/p>\n

Peptides bioactifs et sensation de sati\u00e9t\u00e9<\/strong><\/p>\n

Ces peptides bioactifs agissent sur la sati\u00e9t\u00e9 par interaction avec les hormones de la sati\u00e9t\u00e9. Il est bien d\u00e9montr\u00e9 que les peptides bioactifs d\u00e9riv\u00e9s de la cas\u00e9ine et des prot\u00e9ines de lactos\u00e9rum stimulent la s\u00e9cr\u00e9tion de la chol\u00e9cystokinine (CCK) 6<\/a><\/sup>,10<\/a><\/sup>, hormone connue pour son effet sur la prise alimentaire et la sati\u00e9t\u00e9 14<\/a><\/sup>.<\/p>\n

 <\/p>\n

Les peptides bioactifs stimulent la s\u00e9cr\u00e9tion de la chol\u00e9cystokinine, hormone connue pour son effet sur la prise alimentaire et la sati\u00e9t\u00e9.<\/p><\/blockquote>\n

Les prot\u00e9ines de lait stimulent \u00e9galement la s\u00e9cr\u00e9tion du peptide tyrosine-tyrosine (PYY), hormone \u00e9galement impliqu\u00e9e dans la sensation de sati\u00e9t\u00e9\u00a0; en parall\u00e8le, les prot\u00e9ines de lait r\u00e9priment la s\u00e9cr\u00e9tion de ghr\u00e9line, hormone favorisant la prise alimentaire 1<\/a><\/sup>,11<\/a><\/sup>.<\/p>\n

Interactions entre peptides bioactifs et incr\u00e9tines<\/strong><\/p>\n

Les travaux de recherche ont \u00e9galement d\u00e9montr\u00e9 l\u2019action des peptides bioactifs sur la s\u00e9cr\u00e9tion d\u2019incr\u00e9tines, \u00e0 savoir le glucagon-like-peptide-1<\/em> (GLP-1) et le glucagon inhibitory peptide<\/em> (GIP). Ces deux hormones, s\u00e9cr\u00e9t\u00e9es par l\u2019intestin au moment du passage du bol alimentaire, accentuent la production d\u2019insuline par le pancr\u00e9as. De cette mani\u00e8re, l\u2019organisme re\u00e7oit un signal de \u00ab fin de repas\u00a0\u00bb plus important, induisant une meilleure sensation de sati\u00e9t\u00e9 11<\/a><\/sup>. En plus de stimuler la s\u00e9cr\u00e9tion de ces hormones, les peptides bioactifs pourraient \u00e9galement prolonger leur demi-vie en inhibant la dipeptidyl peptidase-4 (DPP4), responsable de la d\u00e9gradation des incr\u00e9tines. Le tripeptide Ile-Pro-Ala, issu des prot\u00e9ines de lactos\u00e9rum, a ainsi \u00e9t\u00e9 identifi\u00e9 comme inhibiteur de la DPP4 15<\/a><\/sup>.<\/p>\n

Insistons sur le fait que c\u2019est l\u2019association unique des acides amin\u00e9s en peptides bioactifs qui entra\u00eenent ces s\u00e9cr\u00e9tions d\u2019hormones sati\u00e9tog\u00e8nes ; les m\u00eames acides amin\u00e9s, ind\u00e9pendants les uns des autres, n\u2019ont pas cet effet. Ainsi, des acides amin\u00e9s \u00e0 cha\u00eene branch\u00e9e (BCAA) n\u2019ont pas le m\u00eame effet sur la s\u00e9cr\u00e9tion de glucagon inhibitory peptide<\/em> (GIP) qu\u2019une boisson comportant des prot\u00e9ines de lactos\u00e9rum\u00a0; ces derni\u00e8res conduisent \u00e0 une hausse de la s\u00e9cr\u00e9tion en GIP, alors que les BCAA isol\u00e9s n\u2019ont aucun impact 13<\/a><\/sup>.<\/p>\n

 <\/p>\n

\"\"<\/p>\n

Fig\u00a0: Les effets des prot\u00e9ines laiti\u00e8res sur la sati\u00e9t\u00e9<\/u><\/em><\/p>\n

 <\/p>\n

Cas\u00e9ines vs. Prot\u00e9ines de lactos\u00e9rum\u00a0: une question de temps<\/strong><\/p>\n

Par rapport aux effets sati\u00e9tog\u00e8nes, la diff\u00e9rence entre cas\u00e9ines et prot\u00e9ines de lactos\u00e9rum est temporelle. Les prot\u00e9ines de lactos\u00e9rum agissent \u00e0 court terme\u00a0: une consommation de 45-50 g de prot\u00e9ines de lactos\u00e9rum r\u00e9duit ainsi la prise alimentaire lors d\u2019un repas consomm\u00e9 entre 30 et 90 min apr\u00e8s ingestion des prot\u00e9ines 2<\/a><\/sup>. Les cas\u00e9ines sont en revanche effectives pour des repas consomm\u00e9s environ 3h apr\u00e8s leur ingestion 12<\/a><\/sup>. Ces r\u00e9sultats sont coh\u00e9rents avec la diff\u00e9rence de vitesse de digestibilit\u00e9 des deux types de prot\u00e9ines, et montrent surtout la compl\u00e9mentarit\u00e9 de ces deux types de prot\u00e9ines laiti\u00e8res.<\/p>\n

 <\/p>\n

Cas\u00e9ines et prot\u00e9ines de lactos\u00e9rum sont tout aussi effectives pour agir sur la sati\u00e9t\u00e9 ; elles ne le font cependant pas dans le m\u00eame laps de temps.<\/p><\/blockquote>\n

Sur le plan m\u00e9canistique, les diff\u00e9rences de temporalit\u00e9 ont pu \u00e9galement \u00eatre confirm\u00e9es avec la s\u00e9cr\u00e9tion de GLP-1, une des hormones cl\u00e9 de la sati\u00e9t\u00e9. Si une \u00e9tude clinique a pu montrer que 3h post-repas, la s\u00e9cr\u00e9tion de GLP-1 \u00e9tait significativement plus \u00e9lev\u00e9e avec les prot\u00e9ines de lactos\u00e9rum qu\u2019avec la cas\u00e9ine 10<\/a><\/sup>, d\u2019autres \u00e9tudes ont en revanche montr\u00e9 que la s\u00e9cr\u00e9tion de GLP-1 se maintenait \u00e0 plus long terme apr\u00e8s la consommation de cas\u00e9ine 5<\/a><\/sup>,7<\/a><\/sup>. Ces r\u00e9sultats confirment que les cas\u00e9ines et prot\u00e9ines de lactos\u00e9rum sont tout aussi effectives pour agir sur la sati\u00e9t\u00e9\u00a0; elles ne le font cependant pas dans le m\u00eame laps de temps.<\/p>\n

Conclusion<\/strong><\/p>\n

Les prot\u00e9ines laiti\u00e8res poss\u00e8dent des fonctions physiologiques vari\u00e9es. En particulier, les prot\u00e9ines laiti\u00e8res poss\u00e8dent des effets sati\u00e9tog\u00e8nes, qui s\u2019expliquent par des m\u00e9canismes physiologiques bien document\u00e9s. La g\u00e9n\u00e9ration de peptides bioactifs, qui stimulent la s\u00e9cr\u00e9tion d\u2019incr\u00e9tines, sont des sp\u00e9cificit\u00e9s des prot\u00e9ines laiti\u00e8res qui expliquent leur effet sur la prise alimentaire. En d\u00e9finitive, les b\u00e9n\u00e9fices constat\u00e9s des produits laitiers sur le diab\u00e8te de type 2\/syndrome m\u00e9tabolique peuvent en partie \u00eatre expliqu\u00e9s par ces effets physiologiques tr\u00e8s particuliers des prot\u00e9ines laiti\u00e8res.<\/p>\n

Les \u00e9tudes scientifiques soulignent \u00e9galement la compl\u00e9mentarit\u00e9 des cas\u00e9ines<\/a> et des prot\u00e9ines de lactos\u00e9rum<\/a>, qui ne sont pas \u00e0 opposer\u00a0: en effet, les deux types de prot\u00e9ines ont bien un effet sati\u00e9tog\u00e8ne, mais avec un laps de temps diff\u00e9rent. Cette diff\u00e9rence peut donc \u00eatre mise \u00e0 profit pour cr\u00e9er diff\u00e9rents produits visant \u00e0 induire une sati\u00e9t\u00e9 plus ou moins prolong\u00e9e, selon les besoins du consommateur.<\/p>\n

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\n<\/span>[15] Tulipano, G., Sibilia, V., Caroli, A. M., & Cocchi, D. (2011). Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors. Peptides<\/em>, 32<\/em>(4), 835-838. https:\/\/doi.org\/10.1016\/j.peptides.2011.01.002<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Parmi tous les nutriments pr\u00e9sents dans les aliments, les prot\u00e9ines […]<\/p>\n","protected":false},"featured_media":13945,"template":"","class_list":["post-13955","blog-post","type-blog-post","status-publish","has-post-thumbnail","hentry","blog-category-sante-et-nutrition"],"acf":[],"yoast_head":"\nL\u2019effet sati\u00e9tog\u00e8ne des prot\u00e9ines laiti\u00e8res expliqu\u00e9<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez comment les prot\u00e9ines laiti\u00e8res stimulent la sati\u00e9t\u00e9 gr\u00e2ce aux acides amin\u00e9s et peptides bioactifs, aidant \u00e0 r\u00e9guler la faim et l\u2019apport alimentaire.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lactalisingredients.com\/fr\/news\/blog\/effet-satietogene-des-proteines-laitieres\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" 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